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BioJet™ Oral Therapeutic Delivery Platform

Oral delivery of biotherapeutics designed to improve disease management

Our BioJet™ oral delivery platform uses an ingestible smart capsule designed for needle-free, liquid jet delivery of large molecules to the small intestine for systemic uptake.

The platform has the potential to deliver a broad range of large molecules including monoclonal antibodies, peptides, and nucleic acids. These molecules are currently delivered by injection because they cannot survive stomach acids and they are too large to be absorbed in the intestine. 

Oral delivery can help improve patient convenience, which has been shown to improve patient compliance and associated outcomes.

Needles are associated with poor disease management

38% of people with diabetes miss 4+ injections per week.1

71% higher discontinuation rate for diabetes patients initiating treatment with an injectable GLP-1 agonist vs. those starting oral therapy.2 

42% of patients fail to maintain diabetes treatment due to injection concerns when using an injectable GLP-1 agonist.2

Video: how the BioJet platform works

  • ORAL ADMINISTRATION: Convenient oral capsule the size of a multivitamin
  • NEEDLE-FREE DELIVERY: Liquid jet injection to the small intestine to maximize systemic bioavailability
  • AUTONOMOUS FUNCTION: Enteric trigger for precise timing of drug delivery to the small intestine
 
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Therapeutic challenges

Needle-based therapy leads to poor disease management due to inconsistent dosing.

Large molecules cannot achieve systemic uptake through intestinal absorption.

Other oral delivery technologies require difficult re-formulation and lengthy approval pathways.

BioJet oral delivery approach

Needle-free, oral administration may improve patient compliance and therefore patient outcomes.

Liquid jet delivery into the small intestine maximizes systemic bioavailability.

Use of liquid formulation has the potential to deliver a range of approved large molecules, without reformulation.

BioJet Publications

Evaluation of the pharmacokinetics of GLP-1 receptor agonist delivered through the BioJet™ oral biotherapeutic delivery platform in a porcine model: an update
#BioJet Oral Therapeutic Delivery
Evaluation of the pharmacokinetics of GLP-1 receptor agonist delivered through the BioJet™ oral biotherapeutic delivery platform in a porcine model
#BioJet Oral Therapeutic Delivery
Evaluation of the pharmacokinetics of PGN-OB1 following oral administration of an oral biotherapeutics delivery system (OBDS) in Yucatan swine
#BioJet Oral Therapeutic Delivery
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References

  1. Frost & Sullivan research commissioned by Rani Therapeutics Holdings, Inc. https://ir.ranitherapeutics.com/static-files/b1f080bf-a860-4136-87cb-d6f7c49c1502
  2. Spain CV, Wright JJ, Hahn RM, Wivel A, Martin AA. Self-reported Barriers to Adherence and Persistence to Treatment With Injectable Medications for Type 2 Diabetes. Clin Ther. 2016;38(7):1653-1664.e1.